Albendazole

What is it?

Composition

Albendazole contains the active substance albendazole, which is responsible for the antihelminthic effect of the drug. This compound has the ability to suppress the polymerization of tubulin, a key protein involved in the formation of microtubules necessary for the life of parasites. The auxiliary components included in the composition may vary depending on the form of release (tablets, suspension), but usually include:

• Lactose
• Starch
• Povidone
• Talc
• Other fillers

These ingredients ensure the stability and absorption of the drug in the body, as well as the ease of its use.

How to use?

The correct use of Albendazole requires adherence to the dosage and regimen, which depend on the type of parasitic infection, age and weight of the patient. Usually the drug is taken orally, during or after meals, to improve its absorption in the body. Tablets can be chewed or swallowed whole with plenty of water.

Basic recommendations for use:

1. For the treatment of ascariasis, enterobiasis and ancylostomiasis, a single dose of 400 mg is prescribed for adults and children over 2 years old.
2. For the treatment of giardiasis in children, the dosage is 400 mg once a day for 5 days.
3. For severe infestations or echinococcosis, the course of treatment may include taking a dose of 400 mg twice a day for 28 days with breaks.

It is important to follow the doctors instructions and not exceed the recommended dosages to avoid possible side effects.

How does it work?

Albendazole works by interfering with the biochemical processes of parasites, which leads to their death. The main action of the drug is associated with the inhibition of the polymerization of tubulin, a protein that is the basis for the formation of microtubules in the cells of parasites. Microtubules play a key role in the process of nutrient absorption, movement and cell division.

Disruption of microtubule synthesis leads to depletion of glucose reserves in the cells of parasites, which ultimately causes their death. It is important to note that Albendazole is effective against various stages of parasite development, including eggs, larvae and adults. This makes it a powerful tool for the treatment of many helminthiasis, preventing their further spread and development in the body.

Indications

Albendazole is prescribed for the treatment of a wide range of helminthic infections affecting both children and adults. This drug is especially effective in the treatment of the following conditions:

• Ascariasis is an infection caused by roundworms called ascarids.
• Enterobiasis is a disease associated with pinworms.
• Ancylostomiasis is an infection caused by hookworms.
• Giardiasis is a protozoan infection caused by Giardia.
• Echinococcosis is a parasitic disease caused by echinococci, often requiring long-term treatment.
• Neurocysticercosis is an infection caused by the larvae of the pork tapeworm, which affects the nervous system.
• Trichinellosis is an infection caused by parasitic worms of the genus Trichinella.

Albendazole may also be recommended for the prevention of helminthiasis in endemic regions or in conditions where where the risk of parasite infection is high.

Contraindications

Despite its effectiveness, Albendazole has a number of contraindications that must be taken into account before starting treatment. The drug is not recommended for use in the following cases:

• Hypersensitivity or allergy to albendazole or other components of the drug.
• Pregnancy, especially in the first trimester, since there is a risk of teratogenic effect (impact on fetal development).
• Breastfeeding period, since albendazole can penetrate into breast milk and affect the baby.
• Severe liver dysfunction, since the drug is metabolized in the liver, and its use can worsen the condition.
• Children under 2 years of age - use in this age group is possible only according to strict indications and under the supervision of a doctor.

Before starting treatment, it is important to consult a doctor, especially if the patient has chronic diseases or if he takes other medications, in order to avoid possible complications and adverse reactions.

Side effects

Some side effects are possible when taking Albendazole, although not all patients experience them. The most common reactions are:

• Gastrointestinal: nausea, abdominal pain, diarrhea, sometimes vomiting.
• Central nervous system: headache, dizziness, sometimes drowsiness or insomnia.
• Allergic reactions: skin rash, itching, in rare cases - urticaria.
• Liver: a temporary increase in the level of liver enzymes (transaminases) in the blood is possible.
• General reactions: fatigue, weakness, sometimes an increase in body temperature.

If severe or prolonged side effects occur during treatment, you must consult a doctor. It is also important to adhere to the prescribed dosage and regimen to minimize the risk of adverse reactions.