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Plavix

Plavix - Clopidogrel

Active ingredients: Clopidogrel
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What is it?

Plavix is a medication widely used to prevent blood clots that can lead to heart attacks, strokes, and other serious cardiovascular complications. Its active ingredient is clopidogrel, which belongs to a group of antithrombotic drugs known as platelet aggregation inhibitors. These drugs work by preventing platelets from sticking together and forming clots in blood vessels, which is especially important for patients with certain cardiovascular diseases or after surgeries such as stenting.

Plavix is often prescribed to patients who have had a myocardial infarction, ischemic stroke, or who suffer from acute coronary syndrome. This drug helps reduce the risk of recurrent cardiovascular events, making it an important part of comprehensive treatment and prevention in such patients. In addition, Plavix can be recommended for various conditions associated with a high risk of blood clots, which emphasizes its importance in modern medicine.

Composition

The main active ingredient in Plavix is clopidogrel. Each tablet contains a specific dosage of this substance, usually 75 mg. Clopidogrel is a powerful antithrombotic agent that acts on platelets, preventing them from sticking together and forming blood clots.

The excipients included in the drug include:

  • anhydrous calcium hydrogen phosphate, which is used as a stabilizer;
  • microcrystalline cellulose to give the tablet shape and stability;
  • glycerol dibehenate, used to create a protective tablet shell;
  • macrogol and sodium hydroxide, which are involved in the production of tablets and ensure their stability;
  • methacrylic acid copolymer, which ensures the dissolution of the tablet in the intestine;
  • lactose monohydrate, which acts as a filler;
  • iron oxide (dye), which gives the tablets a characteristic color.

These ingredients ensure not only the delivery of the active substance to the body, but also the stability, effectiveness and safety of the drug throughout the shelf life.

How to use?

Plavix is usually taken orally by swallowing the tablet whole with plenty of water. The medication can be taken with or without food, making it convenient for most patients. However, it is important to stick to the prescribed dosage and take it regularly to maintain stable blood levels and ensure maximum effectiveness.

The standard regimen for Plavix is to take one tablet daily at the dosage prescribed by your doctor. If you miss a dose, it is important to take it as soon as possible. However, if it is almost time for your next dose, you should skip the missed dose and continue taking the medication as usual. Doubling the dose is not recommended.

  1. Take Plavix as directed by your doctor.
  2. Swallow the tablet with plenty of water without chewing it.
  3. Take the medicine at the same time every day to maintain a constant level of the medicine in your body.

If you have questions or concerns about using Plavix, it is important to discuss them with your doctor to avoid potential complications or medication errors.

How does it work?

Plavix works by preventing platelets from sticking together, which significantly reduces the risk of blood clots in blood vessels. Its active ingredient, clopidogrel, is an inhibitor of the P2Y12 receptor on the surface of platelets. This receptor is responsible for activating platelets and then sticking together to form blood clots.

After oral administration, clopidogrel is converted to an active metabolite that irreversibly binds to P2Y12 receptors. This binding blocks the signaling required for platelet aggregation, reducing the likelihood of blood clots. This mechanism of action is especially important for patients who have had cardiovascular events or have had stenting, as they are at increased risk of recurrent thrombosis, which can have serious consequences.

Through this mechanism, Plavix helps prevent the development of such dangerous conditions as myocardial infarction and ischemic stroke, making it an important part of preventive therapy in patients at high risk of thromboembolism.

Indications

Plavix is prescribed for the prevention of blood clots in patients with various cardiovascular diseases. The main indications for this drug include:

  • Prevention of myocardial infarction and ischemic stroke in patients who have already suffered these conditions, as well as in those who are at risk for developing these diseases.
  • Acute coronary syndrome, including unstable angina and myocardial infarction with and without ST segment elevation, in combination with acetylsalicylic acid.
  • Prevention of thrombosis in patients after coronary artery stenting or coronary artery bypass grafting.
  • Prevention of peripheral arterial disease, which can lead to serious complications such as limb amputation or severe forms of ischemia.

Plavix is also used in a number of other conditions where there is an increased risk of blood clots, which emphasizes its important role in maintaining cardiovascular health.

Contraindications

The use of Plavix is contraindicated in a number of cases where its use may harm the patients health. The main contraindications include:

  • Hypersensitivity or allergic reaction to clopidogrel or other components of the drug.
  • Active bleeding, such as peptic ulcers, intracranial hemorrhage or other conditions associated with the risk of severe bleeding.
  • Severe liver failure, which can affect the metabolism of clopidogrel and increase the risk of complications.
  • Pregnancy and breastfeeding, unless the potential benefit outweighs the risks to the mother and child, which requires special caution and consultation with a doctor.
  • Hereditary diseases associated with lactase deficiency, galactosemia or glucose-galactose malabsorption, since Plavix contains lactose.

Before starting treatment with Plavix, it is important to discuss with your doctor all existing diseases and conditions that may affect safety of taking the drug. This will help to avoid possible complications and choose the optimal treatment regimen.

Side effects

Like any medicine, Plavix can cause side effects, although not everyone gets them. The most common side effects are related to the drugs effect on the blood clotting system, but other symptoms may also occur.

  • Increased tendency to bleed. This may manifest itself in the form of nosebleeds, bleeding gums, bruising, and increased bleeding time from cuts.
  • Gastrointestinal disorders such as abdominal pain, indigestion, nausea, or diarrhea, which may occur during treatment.
  • Allergic reactions, including skin rashes, itching, swelling, or other manifestations of hypersensitivity, including anaphylactic reactions in rare cases.
  • Thrombocytopenia is a decrease in the level of platelets in the blood, which can increase the risk of bleeding.
  • Headaches, dizziness, and general weakness may also be associated with taking Plavix, especially at the beginning of treatment.

If any of these symptoms or other unusual reactions occur, it is important to consult a doctor immediately. A specialist will be able to adjust the dosage or suggest an alternative treatment if the side effects are significant.

Frequently asked questions

How much does Plavix cost in pharmacies?
Price Plavix in different pharmacies in United Arab Emirates varies. We got it 2.73 AED per pill
How to buy Plavix over the counter?
Plavix it is available over the counter in our pharmacy.

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